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Knochenstoffwechsel

Knochenstoffwechsel

Beitragvon BObermayer-Pietsch » 20.03.2014, 07:03

Wegen des intensiv diskutierten Themas Knochenstoffwechsel bitte die jüngst online erschienene Arbeit von Helena Johansson et al. in Calcified Tissue 4.3.2014 aufnehmen -

"A Meta-Analysis of Reference Markers of Bone Turnover for Prediction of Fracture"
Helena Johansson • Anders Ode´n • John A. Kanis • Eugene V. McCloskey •
Howard A. Morris • Cyrus Cooper • Samuel Vasikaran •
IFCC-IOF Joint Working Group on Standardisation of Biochemical Markers of Bone Turnover
DOI 10.1007/s00223-014-9842-y

Zitat: There was a significant association between
s-PINP and the risk of fracture. The hazard ratio per SD
increase in s-PINP (gradient of risk [GR]) was 1.23 (95 %
CI 1.09–1.39) for men and women combined unadjusted
for bone mineral density. There was also a significant
association between s-CTX and risk of fracture,
GR = 1.18 (95 % CI 1.05–1.34) unadjusted for bone
mineral density. For the outcome of hip fracture, the
association between s-CTX and risk of fracture was slightly
higher, 1.23 (95 % CI 1.04–1.47). Thus, there is a modest
but significant association between BTMs and risk of future
fractures.
BObermayer-Pietsch
 

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